The health benefits of cannabidiol (CBD) are making it popular among its users, and they are using health and wellness products made using it to treat a wide variety of ailments. For example, it used for treating common ailments like headaches, pain, swelling, wound healing, skin issues like irritation, infections, etc. Because of this, manufacturers are introducing different types of cannabidiol products. Among them, ingestible items have higher demand because of their systemic therapeutic effects. One of the most popular cannabidiol products is CBD oil, and here we will investigate about overdosing CBD and the resulting side effects.
How CBD Oil Works In The Body?
CBD health benefits are due to cannabidiol’s positive effect on the endocannabinoid system (ECS) of our body mainly by interacting with CB1 and CB2 receptors of this system. Apart from this, CBD also produces its effects by acting on 60 molecular pathways. When you ingest CBD oil, it passes through the digestive system, where it is absorbed into the bloodstream. From there, it is carried through the hepatic portal vein to the liver.
In the liver, cannabidiol (CBD) is metabolized by a group of enzymes called Cytochrome P450 (CYP40) into constituent metabolites. Some of them are useful and they become available to the ECS, while the unusable ones are eliminated out of the body. However, you must also know that CBD has the effect of reducing the metabolic action of CYP450, and this in turn reduces livers metabolism.
Is It Possible To Overdose On CBD Oil?
It has been found from research that cannabinoids like CBD are nontoxic, and there have been no reported cases of fatal overdosing. Moreover, studies show that a daily dose of up to 1500 mg of CBD is well tolerated in humans. However, this can cause side effects, and the severity depends on the amount of CBD consumed.
Cannabidiol (CBD) Side Effects
Dry Mouth: This is one of the most common side effects among many first-time cannabidiol users, and it can be dealt with by drinking water before and after consuming CBD oil.
Low Blood Pressure: At higher doses, CBD oil is known to lower blood pressure, and this can be problematic for people consuming medicines for high blood pressure. You should also know that one of CBD’s therapeutic effects is its vasodilatory effect.
Drowsiness: Consuming CBD oil makes you feel relaxed and calm because of its positive effect on the ECS. However, at higher doses, this same effect can make you feel drowsy, and this usually happens at doses of more than 100 mg of CBD.
Diarrhea: In some people, CBD oil results in diarrhea, and this is because of its effect on ECS that also regulates gastrointestinal function.
These are the points that you should be aware of regarding the overdosing and side effects of CBD oil.